Version 5.4
| Mus musculus Gene: Hepacam | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-150034.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | Hepacam | ||||||||||||||||||
| Gene Name | hepatocyte cell adhesion molecule | ||||||||||||||||||
| Synonyms | 2900042E01Rik; Hepn1 | ||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||
| Ensembl Gene | ENSMUSG00000046240 | ||||||||||||||||||
| Encoded Proteins |
hepatocyte cell adhesion molecule
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165478:
This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). Also to note is that this gene maps to the 3'-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand (PMID:15885354). [provided by RefSeq, Aug 2011] The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 9:37367368-37386572 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | A4 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||||||||||||
| SwissProt | Q640R3 | ||||||||||||||||||
| TrEMBL | B2RSY3 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 72927 | ||||||||||||||||||
| UniGene | Mm.266133 | ||||||||||||||||||
| RefSeq | NM_175189 XM_006510638 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS22976 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| MGI ID | MGI:1920177 | ||||||||||||||||||
| MGI Symbol | Hepacam | ||||||||||||||||||
| EMBL | AC138284 BC082537 BC139057 BC139058 CH466522 | ||||||||||||||||||
| GenPept | AAH82537 AAI39058 AAI39059 EDL25426 | ||||||||||||||||||
| RNA Seq Atlas | 72927 | ||||||||||||||||||