Version 5.4
Bos taurus Gene: HEPACAM
Summary
InnateDB Gene IDBG-642655.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HEPACAM
Gene Name Hepatocyte cell adhesion molecule
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018650
Encoded Proteins
IDBP-695128
Hepatocyte cell adhesion molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165478:
This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). Also to note is that this gene maps to the 3'-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand (PMID:15885354). [provided by RefSeq, Aug 2011] The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:28751164-28767534
Strand Reverse strand
Band
Transcripts
ENSBTAT00000030296 ENSBTAP00000030280
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007049 cell cycle
GO:0007050 cell cycle arrest
GO:0007155 cell adhesion
GO:0034613 cellular protein localization
GO:0040008 regulation of growth
Cellular Component
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000165478
View Gene Order
ENSMUSG00000046240
View Gene Order
Cross-References
SwissProt A4FUY1
TrEMBL
UniProt Splice Variant
Entrez Gene 521015
UniGene Bt.37391
RefSeq NM_001031759 XM_005226797 XM_005226798
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123427 BT021628
GenPept AAI23428 AAX46475
RNA Seq Atlas 521015

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca