InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dbh

Summary

InnateDB Gene

IDBG-150816.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dbh

Gene Name

dopamine beta hydroxylase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000889

Encoded Proteins

IDBP-150818

dopamine beta hydroxylase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123454:
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:27165233-27183200

Strand

Forward strand

Band

Transcripts

ENSMUST00000000910	ENSMUSP00000000910
ENSMUST00000155290

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004497	monooxygenase activity
GO:0004500	dopamine beta-monooxygenase activity
GO:0005507	copper ion binding
GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0001816	cytokine production
GO:0001974	blood vessel remodeling
GO:0001975	response to amphetamine
GO:0002443	leukocyte mediated immunity
GO:0007613	memory
GO:0007626	locomotory behavior
GO:0008306	associative learning
GO:0008542	visual learning
GO:0042127	regulation of cell proliferation
GO:0042309	homoiothermy
GO:0042420	dopamine catabolic process
GO:0042421	norepinephrine biosynthetic process
GO:0042593	glucose homeostasis
GO:0042596	fear response
GO:0042711	maternal behavior
GO:0045907	positive regulation of vasoconstriction
GO:0048149	behavioral response to ethanol
GO:0048265	response to pain
GO:0050900	leukocyte migration
GO:0055114	oxidation-reduction process
GO:2001236	regulation of extrinsic apoptotic signaling pathway