Version 5.4
Mus musculus Gene: Herc6
Summary
InnateDB Gene IDBG-151109.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Herc6
Gene Name hect domain and RLD 6
Synonyms 1700121D12Rik; 2510038N07Rik; 4930427L17Rik; AI451296; CEB1; Herc5
Species Mus musculus
Ensembl Gene ENSMUSG00000029798
Encoded Proteins
IDBP-151113
hect domain and RLD 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138642:
HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:57580992-57665136
Strand Forward strand
Band B3
Transcripts
ENSMUST00000031817 ENSMUSP00000031817
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0016874 ligase activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138642
View Gene Order
ENSBTAG00000020536
Not yet available
Cross-References
SwissProt F2Z461
TrEMBL
UniProt Splice Variant
Entrez Gene 67138
UniGene Mm.297393
RefSeq NM_025992
OMIM
CCDS CCDS51796
HPRD
IMGT
MGI ID MGI:1914388
MGI Symbol Herc6
EMBL AC127307 AC142212 AK017888 AK149648
GenPept BAB30989 BAE29004
RNA Seq Atlas 67138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca