Version 5.4
Bos taurus Gene: HERC6
Summary
InnateDB Gene IDBG-641150.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HERC6
Gene Name probable E3 ubiquitin-protein ligase HERC6
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020536
Encoded Proteins
IDBP-693482
hect domain and RLD 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138642:
HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:37736138-37793279
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027362 ENSBTAP00000027362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0016874 ligase activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0008152 metabolic process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000138642
View Gene Order
ENSMUSG00000029798
View Gene Order
Cross-References
SwissProt
TrEMBL F1N7C1 Q2PC22
UniProt Splice Variant
Entrez Gene 527520
UniGene Bt.42179
RefSeq NM_001192644
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ871965 DAAA02017014
GenPept CAI44836
RNA Seq Atlas 527520

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca