InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fcnb

Summary

InnateDB Gene

IDBG-151717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fcnb

Gene Name

ficolin B

Synonyms

Fcn2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026835

Encoded Proteins

IDBP-151719

ficolin B

IDBP-400788

ficolin B

IDBP-538855

ficolin B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23150716

Fcnb is crucial for the induction of innate immunity against pneumococcal infection through the lectin complement pathway.

InnateDB Annotation from Orthologs

Summary

PMID 20375620

[Homo sapiens] FCN1, as well as ficolins FCN2 and FCN3, in serum are associated with MBL-associated serine protease (MASP) to form a complex and this complex binds to carbohydrates present on the surface of a variety of Gram-positive and Gram-negative bacteria through ficolin, initiating complement activation via the lectin pathway.

PMID 16116205

[Homo sapiens] FCN1, like its family members, functions as a recognition molecule of the lectin complement pathway and plays an important role in innate immunity.

PMID 21490156

[Homo sapiens] FCN3 and PTX3 are soluble oligomeric pattern-recognition molecules that interact with each other and act synergistically to activate the lectin complement pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085265:
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:28076378-28084885

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028179	ENSMUSP00000028179
ENSMUST00000117486	ENSMUSP00000112625
ENSMUST00000135472	ENSMUSP00000119098

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.