InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FCN2

Summary

InnateDB Gene

IDBG-641596.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCN2

Gene Name

Ficolin-2

Synonyms

FCN2; FCNB

Species

Bos taurus

Ensembl Gene

ENSBTAG00000048155

Encoded Proteins

IDBP-693976

Ficolin-2

IDBP-693977

Ficolin-2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20375620

[Homo sapiens] FCN1, as well as ficolins FCN2 and FCN3, in serum are associated with MBL-associated serine protease (MASP) to form a complex and this complex binds to carbohydrates present on the surface of a variety of Gram-positive and Gram-negative bacteria through ficolin, initiating complement activation via the lectin pathway.

PMID 16116205

[Homo sapiens] FCN1, like its family members, functions as a recognition molecule of the lectin complement pathway and plays an important role in innate immunity.

PMID 21490156

[Homo sapiens] FCN3 and PTX3 are soluble oligomeric pattern-recognition molecules that interact with each other and act synergistically to activate the lectin complement pathway.

PMID 23150716

[Mus musculus] Fcnb is crucial for the induction of innate immunity against pneumococcal infection through the lectin complement pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085265:
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:106822997-106831824

Strand

Forward strand

Band

Transcripts

ENSBTAT00000065623	ENSBTAP00000055640
ENSBTAT00000066000	ENSBTAP00000054518

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.