Version 5.4
Mus musculus Gene: Bcam
Summary
InnateDB Gene IDBG-152453.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcam
Gene Name basal cell adhesion molecule
Synonyms 1200005K12Rik; B-CAM; Gplu; Lu
Species Mus musculus
Ensembl Gene ENSMUSG00000002980
Encoded Proteins
IDBP-152455
basal cell adhesion molecule
IDBP-531929
basal cell adhesion molecule
IDBP-533827
basal cell adhesion molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187244:
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:19756131-19771016
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000003061 ENSMUSP00000003061
ENSMUST00000135632
ENSMUST00000133271
ENSMUST00000155244 ENSMUSP00000121145
ENSMUST00000133427 ENSMUSP00000117998
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005055 laminin receptor activity
GO:0005515 protein binding
GO:0043236 laminin binding
Biological Process
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000187244
View Gene Order
ENSBTAG00000009495
Not yet available
Cross-References
SwissProt
TrEMBL D3YTK7
UniProt Splice Variant
Entrez Gene 57278
UniGene Mm.29236
RefSeq NM_020486 XM_006540237
OMIM
CCDS CCDS39803
HPRD
IMGT
MGI ID MGI:1929940
MGI Symbol Bcam
EMBL AC149282
GenPept
RNA Seq Atlas 57278

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca