Version 5.4
Homo sapiens Gene: BCAM
Summary
InnateDB Gene IDBG-56639.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCAM
Gene Name basal cell adhesion molecule (Lutheran blood group)
Synonyms AU; CD239; LU; MSK19
Species Homo sapiens
Ensembl Gene ENSG00000187244
Encoded Proteins
IDBP-56641
basal cell adhesion molecule (Lutheran blood group)
IDBP-765553
IDBP-765765
IDBP-812667
basal cell adhesion molecule (Lutheran blood group)
IDBP-812675
basal cell adhesion molecule (Lutheran blood group)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:44809059-44821420
Strand Forward strand
Band q13.32
Transcripts
ENST00000270233 ENSP00000270233
ENST00000588603
ENST00000590108
ENST00000591520 ENSP00000467100
ENST00000590196 ENSP00000468189
ENST00000589651 ENSP00000476710
ENST00000590624
ENST00000588303
ENST00000589558
ENST00000588714
ENST00000611077 ENSP00000481153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005055 laminin receptor activity
GO:0005515 protein binding
GO:0043236 laminin binding
Biological Process
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002980
View Gene Order
ENSBTAG00000009495
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.625725
RefSeq NM_001013257 NM_005581
HUGO
OMIM
CCDS CCDS12644 CCDS42575
HPRD 00197
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca