Version 5.4
Bos taurus Gene: BCAM
Summary
InnateDB Gene IDBG-639282.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCAM
Gene Name Basal cell adhesion molecule
Synonyms LU
Species Bos taurus
Ensembl Gene ENSBTAG00000009495
Encoded Proteins
IDBP-691422
Basal cell adhesion molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187244:
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:52965138-52976445
Strand Forward strand
Band
Transcripts
ENSBTAT00000012495 ENSBTAP00000012495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005055 laminin receptor activity
GO:0005515 protein binding
GO:0043236 laminin binding
Biological Process
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000187244
View Gene Order
ENSMUSG00000002980
View Gene Order
Cross-References
SwissProt Q9MZ08
TrEMBL
UniProt Splice Variant
Entrez Gene 282862
UniGene Bt.7873
RefSeq NM_174741
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF270512 BC123496
GenPept AAF81749 AAI23497
RNA Seq Atlas 282862

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca