Version 5.4
Mus musculus Gene: Hrh2
Summary
InnateDB Gene IDBG-153383.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hrh2
Gene Name histamine receptor H2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000034987
Encoded Proteins
IDBP-153385
histamine receptor H2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113749:
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:54192129-54222432
Strand Forward strand
Band B1
Transcripts
ENSMUST00000038101 ENSMUSP00000038170
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004969 histamine receptor activity
Biological Process
GO:0001696 gastric acid secretion
GO:0001697 histamine-induced gastric acid secretion
GO:0001698 gastrin-induced gastric acid secretion
GO:0003382 epithelial cell morphogenesis
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007613 memory
GO:0008542 visual learning
GO:0045907 positive regulation of vasoconstriction
GO:0048167 regulation of synaptic plasticity
GO:0048565 digestive tract development
GO:0048732 gland development
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113749
View Gene Order
ENSBTAG00000044071
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04971
Gastric acid secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_16903
Histamine receptors pathway
REACT_16983
Amine ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
hsa04971
Gastric acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt P97292
TrEMBL Q3ZB30 Q9QX37
UniProt Splice Variant
Entrez Gene 15466
UniGene Mm.57243
RefSeq NM_001010973 NM_008286 XM_006516852
OMIM
CCDS CCDS26526
HPRD
IMGT
MGI ID MGI:108482
MGI Symbol Hrh2
EMBL AB444633 AB444634 AC163343 AC164086 AF019138 AF513034 AF513035 AK020259 AK163760 BC103553 BC103554 D50096
GenPept AAD01634 AAI03554 AAI03555 AAM47009 AAM47010 BAA08792 BAB32044 BAE37484 BAG66243 BAG66244
RNA Seq Atlas 15466

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca