InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mdh1

Summary

InnateDB Gene

IDBG-153492.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mdh1

Gene Name

malate dehydrogenase 1, NAD (soluble)

Synonyms

B230377B03Rik; D17921; MDH-s; MDHA; Mor-2; Mor2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020321

Encoded Proteins

IDBP-153494

malate dehydrogenase 1, NAD (soluble)

IDBP-539764

malate dehydrogenase 1, NAD (soluble)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000014641:
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:21556787-21572367

Strand

Reverse strand

Band

A3.1

Transcripts

ENSMUST00000102874	ENSMUSP00000099938
ENSMUST00000146146
ENSMUST00000144978
ENSMUST00000125302	ENSMUSP00000119816

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0016491	oxidoreductase activity
GO:0016615	malate dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060	L-malate dehydrogenase activity
GO:0051287	NAD binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006099	tricarboxylic acid cycle
GO:0006107	oxaloacetate metabolic process
GO:0006108	malate metabolic process
GO:0006734	NADH metabolic process
GO:0019674	NAD metabolic process
GO:0044262	cellular carbohydrate metabolic process
GO:0055114	oxidation-reduction process