InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MDH1

Summary

InnateDB Gene

IDBG-635509.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MDH1

Gene Name

Malate dehydrogenase, cytoplasmic

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019295

Encoded Proteins

IDBP-687351

Malate dehydrogenase, cytoplasmic

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000014641:
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:61970467-61994479

Strand

Forward strand

Band

Transcripts

ENSBTAT00000025691

ENSBTAP00000025691

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0016491	oxidoreductase activity
GO:0016615	malate dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060	L-malate dehydrogenase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006099	tricarboxylic acid cycle
GO:0006108	malate metabolic process
GO:0044262	cellular carbohydrate metabolic process
GO:0055114	oxidation-reduction process