Version 5.4
Homo sapiens Gene: RHOT2
Summary
InnateDB Gene IDBG-7970.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHOT2
Gene Name ras homolog family member T2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140983
Encoded Proteins
IDBP-7972
ras homolog gene family, member T2
IDBP-744825
IDBP-750987
IDBP-750203
IDBP-752012
IDBP-750874
IDBP-747547
IDBP-745454
IDBP-754647
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:668086-674174
Strand Forward strand
Band p13.3
Transcripts
ENST00000315082 ENSP00000321971
ENST00000570092
ENST00000570280 ENSP00000454486
ENST00000566214 ENSP00000455138
ENST00000566965
ENST00000563134 ENSP00000459564
ENST00000569197 ENSP00000457437
ENST00000568950
ENST00000562598
ENST00000567589
ENST00000569358
ENST00000565004
ENST00000561929 ENSP00000456855
ENST00000564659
ENST00000562957
ENST00000569943
ENST00000561711
ENST00000561983 ENSP00000454307
ENST00000562333 ENSP00000457852
ENST00000567017
ENST00000562708
ENST00000569706
ENST00000569675
ENST00000568636
ENST00000563637 ENSP00000458136
ENST00000563776
ENST00000602564
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0019725 cellular homeostasis
GO:0047497 mitochondrion transport along microtubule
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097345 mitochondrial outer membrane permeabilization
Cellular Component
GO:0005622 intracellular
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031307 integral component of mitochondrial outer membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025733
View Gene Order
ENSBTAG00000004551
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H3BP40
UniProt Splice Variant
Entrez Gene 89941
UniGene Hs.513242 Hs.737113
RefSeq NM_138769 XM_005255660 XM_005255664 XM_006720970 XM_006720971
HUGO HGNC:21169
OMIM 613889
CCDS CCDS10417
HPRD 15248
IMGT
EMBL Z92544
GenPept
RNA Seq Atlas 89941

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca