InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GLRB

Summary

InnateDB Gene

IDBG-630612.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLRB

Gene Name

glycine receptor subunit beta precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021764

Encoded Proteins

IDBP-682090

glycine receptor subunit beta precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109738:
This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:42999060-43205751

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000029010

ENSBTAP00000029010

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005488	binding
GO:0005515	protein binding
GO:0016594	glycine binding
GO:0016933	extracellular-glycine-gated ion channel activity
GO:0016934	extracellular-glycine-gated chloride channel activity

Biological Process

GO:0001964	startle response
GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0007340	acrosome reaction
GO:0007399	nervous system development
GO:0007601	visual perception
GO:0007628	adult walking behavior
GO:0034220	ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0050905	neuromuscular process
GO:0060012	synaptic transmission, glycinergic
GO:0060013	righting reflex
GO:1902476	chloride transmembrane transport