Version 5.4
Mus musculus Gene: Crtam
Summary
InnateDB Gene IDBG-153804.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crtam
Gene Name cytotoxic and regulatory T cell molecule
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032021
Encoded Proteins
IDBP-153806
cytotoxic and regulatory T cell molecule
IDBP-742583
IDBP-742325
IDBP-787703
cytotoxic and regulatory T cell molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109943:
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:40972753-41004628
Strand Reverse strand
Band A5.1
Transcripts
ENSMUST00000034519 ENSMUSP00000034519
ENSMUST00000180384 ENSMUSP00000137837
ENSMUST00000180872 ENSMUSP00000137749
ENSMUST00000188848 ENSMUSP00000139826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0002355 detection of tumor cell
GO:0002376 immune system process
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0008037 cell recognition
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050715 positive regulation of cytokine secretion
GO:0051606 detection of stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109943
View Gene Order
ENSBTAG00000005193
Not yet available
Pathways
NETPATH
REACTOME
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_230745
Immune System pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.42791
RefSeq NM_001281954 NM_019465
OMIM
CCDS CCDS72216
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca