Version 5.4
Mus musculus Gene: Pdgfc
Summary
InnateDB Gene IDBG-153854.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdgfc
Gene Name platelet-derived growth factor, C polypeptide
Synonyms 1110064L01Rik; AI647969; PDGF-C
Species Mus musculus
Ensembl Gene ENSMUSG00000028019
Encoded Proteins
IDBP-153856
platelet-derived growth factor, C polypeptide
IDBP-542901
platelet-derived growth factor, C polypeptide
IDBP-542903
platelet-derived growth factor, C polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145431:
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:81036416-81214040
Strand Forward strand
Band E3
Transcripts
ENSMUST00000029652 ENSMUSP00000029652
ENSMUST00000129285 ENSMUSP00000118970
ENSMUST00000143721 ENSMUSP00000122047
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0008284 positive regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0045740 positive regulation of DNA replication
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048146 positive regulation of fibroblast proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0051781 positive regulation of cell division
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145431
View Gene Order
ENSBTAG00000043959
Not yet available
Pathways
NETPATH
REACTOME
REACT_263353
Signaling by PDGF pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04540
Gap junction pathway
mmu05218
Melanoma pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu05215
Prostate cancer pathway
mmu04510
Focal adhesion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04540
Gap junction pathway
hsa05218
Melanoma pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
INOH
PID NCI
pdgf_pathway
PDGF receptor signaling network
Cross-References
SwissProt Q8CI19
TrEMBL
UniProt Splice Variant
Entrez Gene 54635
UniGene Mm.331089 Mm.397261 Mm.466049
RefSeq NM_019971 XM_006501712
OMIM
CCDS CCDS17425
HPRD
IMGT
MGI ID MGI:1859631
MGI Symbol Pdgfc
EMBL AF117608 AF266467 AF286725 AK033734 AK042767 AK052947 BC006027 BC037696
GenPept AAF22516 AAF91483 AAH06027 AAH37696 AAK58566 BAC28455 BAC31358 BAC35216
RNA Seq Atlas 54635

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca