Version 5.4
Mus musculus Gene: Parp10
Summary
InnateDB Gene IDBG-154210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Parp10
Gene Name poly (ADP-ribose) polymerase family, member 10
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000063268
Encoded Proteins
IDBP-154212
poly (ADP-ribose) polymerase family, member 10
IDBP-625546
poly (ADP-ribose) polymerase family, member 10
IDBP-625560
poly (ADP-ribose) polymerase family, member 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178685:
Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:76231174-76243441
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000075689 ENSMUSP00000075110
ENSMUST00000170226 ENSMUSP00000131370
ENSMUST00000165738 ENSMUSP00000129765
ENSMUST00000166151
ENSMUST00000169255
ENSMUST00000170851
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0070530 K63-linked polyubiquitin binding
Biological Process
GO:0006471 protein ADP-ribosylation
GO:0010629 negative regulation of gene expression
GO:0010847 regulation of chromatin assembly
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033159 negative regulation of protein import into nucleus, translocation
GO:0045071 negative regulation of viral genome replication
GO:0048147 negative regulation of fibroblast proliferation
GO:0070212 protein poly-ADP-ribosylation
GO:0070213 protein auto-ADP-ribosylation
GO:1900045 negative regulation of protein K63-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178685
View Gene Order
ENSBTAG00000009677
Not yet available
Cross-References
SwissProt
TrEMBL Q3U6C0 Q8C8L6 Q8CIE4 Q8R1U9
UniProt Splice Variant
Entrez Gene 671535
UniGene Mm.373750
RefSeq NM_001163575 NM_001163576
OMIM
CCDS CCDS49650
HPRD
IMGT
MGI ID MGI:3712326
MGI Symbol Parp10
EMBL AC110211 AK046755 AK153205 BC023056 BC024074
GenPept AAH23056 AAH24074 BAC32856 BAE31805
RNA Seq Atlas 671535

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca