Version 5.4
Mus musculus Gene: Gm10053
Summary
InnateDB Gene IDBG-154821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gm10053
Gene Name predicted gene 10053
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000058927
Encoded Proteins
IDBP-154823
predicted gene 10053
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172115:
This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:24875686-24876634
Strand Forward strand
Band B
Transcripts
ENSMUST00000073080 ENSMUSP00000072829
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0009055 electron carrier activity
GO:0020037 heme binding
Biological Process
GO:0006915 apoptotic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005758 mitochondrial intermembrane space
GO:0070469 respiratory chain
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000172115
View Gene Order
ENSBTAG00000023823
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_189162
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_188957
Cellular responses to stress pathway
REACT_225157
Activation of caspases through apoptosome-mediated cleavage pathway
REACT_268398
Orphan transporters pathway
REACT_262523
Respiratory electron transport pathway
REACT_189141
Detoxification of Reactive Oxygen Species pathway
REACT_188937
Metabolism pathway
REACT_216831
Cytochrome c-mediated apoptotic response pathway
REACT_261922
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_211550
Release of apoptotic factors from the mitochondria pathway
REACT_205251
Transcriptional activation of mitochondrial biogenesis pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_206522
Formation of apoptosome pathway
REACT_211261
Mitochondrial biogenesis pathway
REACT_211477
Apoptotic factor-mediated response pathway
REACT_204001
Intrinsic Pathway for Apoptosis pathway
KEGG
mmu00920
Sulfur metabolism pathway
mmu04115
p53 signaling pathway pathway
mmu05010
Alzheimer's disease pathway
mmu05210
Colorectal cancer pathway
mmu05222
Small cell lung cancer pathway
mmu04210
Apoptosis pathway
mmu05012
Parkinson's disease pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu05016
Huntington's disease pathway
mmu05200
Pathways in cancer pathway
mmu05416
Viral myocarditis pathway
mmu05145
Toxoplasmosis pathway
INOH
INOH website
TNFR1 signaling pathway pathway
INOH website
Fas signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_607
Activation of caspases through apoptosome-mediated cleavage pathway
REACT_89
Formation of apoptosome pathway
REACT_1322
Release of apoptotic factors from the mitochondria pathway
REACT_22393
Respiratory electron transport pathway
REACT_120956
Cellular responses to stress pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
REACT_578
Apoptosis pathway
REACT_267716
Orphan transporters pathway
REACT_963
Apoptotic factor-mediated response pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_831
Cytochrome c-mediated apoptotic response pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_111217
Metabolism pathway
REACT_271057
Orphan transporters pathway
REACT_257304
Activation of caspases through apoptosome-mediated cleavage pathway
REACT_214581
Transcriptional activation of mitochondrial biogenesis pathway
REACT_215469
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_206069
Cellular responses to stress pathway
REACT_246456
Formation of apoptosome pathway
REACT_204534
Detoxification of Reactive Oxygen Species pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_218878
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_244340
Cytochrome c-mediated apoptotic response pathway
REACT_222195
Intrinsic Pathway for Apoptosis pathway
REACT_219139
Metabolism pathway
REACT_223064
Respiratory electron transport pathway
REACT_215578
Release of apoptotic factors from the mitochondria pathway
REACT_205675
Mitochondrial biogenesis pathway
REACT_213329
Apoptotic factor-mediated response pathway
REACT_219454
Apoptosis pathway
REACT_219259
Organelle biogenesis and maintenance pathway
KEGG
hsa05210
Colorectal cancer pathway
hsa04210
Apoptosis pathway
hsa05010
Alzheimer's disease pathway
hsa05222
Small cell lung cancer pathway
hsa00920
Sulfur metabolism pathway
hsa04115
p53 signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
hsa05200
Pathways in cancer pathway
hsa05416
Viral myocarditis pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
TNFR1 signaling pathway pathway
INOH website
Fas signaling pathway pathway
PID NCI
ceramide_pathway
Ceramide signaling pathway
caspase_pathway
Caspase Cascade in Apoptosis
mtor_4pathway
mTOR signaling pathway
p75ntrpathway
p75(NTR)-mediated signaling
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
OMIM
CCDS
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca