Version 5.4
Mus musculus Gene: Ccbe1
Summary
InnateDB Gene IDBG-154939.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccbe1
Gene Name collagen and calcium binding EGF domains 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000046318
Encoded Proteins
IDBP-154941
collagen and calcium binding EGF domains 1
IDBP-540686
collagen and calcium binding EGF domains 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183287:
This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:66045302-66302739
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000061103 ENSMUSP00000052011
ENSMUST00000146610
ENSMUST00000130300 ENSMUSP00000117636
ENSMUST00000151343
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005518 collagen binding
Biological Process
GO:0001946 lymphangiogenesis
GO:0002040 sprouting angiogenesis
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0010595 positive regulation of endothelial cell migration
GO:0010954 positive regulation of protein processing
GO:0045766 positive regulation of angiogenesis
GO:0048845 venous blood vessel morphogenesis
GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway
GO:1901492 positive regulation of lymphangiogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000183287
View Gene Order
ENSBTAG00000008723
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.402022 Mm.442049 Mm.489217
RefSeq NM_178793
OMIM
CCDS CCDS29314
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca