InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Unc5b

Summary

InnateDB Gene

IDBG-154989.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc5b

Gene Name

unc-5 homolog B (C. elegans)

Synonyms

6330415E02Rik; A630020F16; D10Bwg0792e; Unc5h2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020099

Encoded Proteins

IDBP-154991

unc-5 homolog B (C. elegans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107731:
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:60762610-60831581

Strand

Reverse strand

Band

Transcripts

ENSMUST00000077925

ENSMUSP00000077080

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0033564	anterior/posterior axon guidance
GO:0043524	negative regulation of neuron apoptotic process
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand