InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: UNC5B

Summary

InnateDB Gene

IDBG-629823.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UNC5B

Gene Name

netrin receptor UNC5B precursor

Synonyms

UNC5C

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014270

Encoded Proteins

IDBP-681236

netrin receptor UNC5B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107731:
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:27511423-27599754

Strand

Forward strand

Band

Transcripts

ENSBTAT00000018961

ENSBTAP00000018961

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0033564	anterior/posterior axon guidance
GO:0043524	negative regulation of neuron apoptotic process
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand