InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hspe1

Summary

InnateDB Gene

IDBG-155256.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspe1

Gene Name

heat shock protein 1 (chaperonin 10)

Synonyms

10kDa; Hsp10; mt-cpn10

Species

Mus musculus

Ensembl Gene

ENSMUSG00000073676

Encoded Proteins

IDBP-155258

heat shock protein 1 (chaperonin 10)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115541:
This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:55088132-55091307

Strand

Forward strand

Band

C1.2

Transcripts

ENSMUST00000075242	ENSMUSP00000074724
ENSMUST00000134628

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051087	chaperone binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006457	protein folding
GO:0006950	response to stress

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000115541

View Gene Order

ENSBTAG00000012589

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_008303 XM_006543479 XM_888439

OMIM

CCDS

CCDS35570

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas