InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hsf1

Summary

InnateDB Gene

IDBG-155311.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsf1

Gene Name

heat shock factor 1

Synonyms

AA960185; Hsf1alpha; Hsf1beta

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022556

Encoded Proteins

IDBP-155315

heat shock factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22042134

Hsf1 is necessary to initiate host defence against Mycoplasma pneumoniae infection in the lungs through Tlr2 signalling activation.

InnateDB Annotation from Orthologs

Summary

PMID 20018623

[Homo sapiens] HSF1 activated by heat shock induces the expression of ATF3, a negative regulator of IL-6, and ATF3 is necessary for heat-mediated suppression of IL-6, indicating a fever-mediated feedback loop consisting of HSF1 and ATF3.

PMID 22042134

[Homo sapiens] HSF1 is necessary to initiate host defence against Mycoplasma pneumoniae infection in the lungs through TLR2 signalling activation. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185122:
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:76477445-76500972

Strand

Forward strand

Band

Transcripts

ENSMUST00000072838

ENSMUSP00000072617

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006952	defense response
GO:0007143	female meiotic division
GO:0007283	spermatogenesis
GO:0008285	negative regulation of cell proliferation
GO:0009408	response to heat
GO:0032496	response to lipopolysaccharide
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034605	cellular response to heat
GO:0040018	positive regulation of multicellular organism growth
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060136	embryonic process involved in female pregnancy
GO:0090231	regulation of spindle checkpoint