Version 5.4
Mus musculus Gene: F12
Summary
InnateDB Gene IDBG-155659.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F12
Gene Name coagulation factor XII (Hageman factor)
Synonyms FXII; HAF
Species Mus musculus
Ensembl Gene ENSMUSG00000021492
Encoded Proteins
IDBP-155661
coagulation factor XII (Hageman factor)
IDBP-622093
coagulation factor XII (Hageman factor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131187:
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:55417958-55426793
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000021948 ENSMUSP00000021948
ENSMUST00000170921 ENSMUSP00000125771
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0070009 serine-type aminopeptidase activity
Biological Process
GO:0002353 plasma kallikrein-kinin cascade
GO:0002542 Factor XII activation
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0010756 positive regulation of plasminogen activation
GO:0016485 protein processing
GO:0016540 protein autoprocessing
GO:0030193 regulation of blood coagulation
GO:0030194 positive regulation of blood coagulation
GO:0031638 zymogen activation
GO:0042730 fibrinolysis
GO:0051788 response to misfolded protein
GO:0051919 positive regulation of fibrinolysis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131187
View Gene Order
ENSBTAG00000018872
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_239392
Intrinsic Pathway pathway
REACT_235097
Formation of Fibrin Clot (Clotting Cascade) pathway
KEGG
mmu04610
Complement and coagulation cascades pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_326
Intrinsic Pathway pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_604
Hemostasis pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9Q698
UniProt Splice Variant
Entrez Gene 58992
UniGene Mm.42224
RefSeq NM_021489
OMIM
CCDS CCDS36675
HPRD
IMGT
MGI ID MGI:1891012
MGI Symbol F12
EMBL CT009762
GenPept
RNA Seq Atlas 58992

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca