Version 5.4
Mus musculus Gene: Tonsl
Summary
InnateDB Gene IDBG-156338.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tonsl
Gene Name tonsoku-like, DNA repair protein
Synonyms 1110014J03Rik; 2810439M11Rik; AI847241; D730005C08Rik; Nfkbil2
Species Mus musculus
Ensembl Gene ENSMUSG00000059323
Encoded Proteins
IDBP-626526
tonsoku-like, DNA repair protein
IDBP-626535
tonsoku-like, DNA repair protein
IDBP-626536
tonsoku-like, DNA repair protein
IDBP-626537
tonsoku-like, DNA repair protein
IDBP-626538
tonsoku-like, DNA repair protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160949:
The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:76622088-76639958
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000165163 ENSMUSP00000131229
ENSMUST00000168185 ENSMUSP00000129597
ENSMUST00000163990
ENSMUST00000171478 ENSMUSP00000129471
ENSMUST00000165190 ENSMUSP00000131368
ENSMUST00000163161
ENSMUST00000168432
ENSMUST00000166974 ENSMUSP00000126362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042393 histone binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0015031 protein transport
GO:0031297 replication fork processing
GO:0031397 negative regulation of protein ubiquitination
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Cellular Component
GO:0000813 ESCRT I complex
GO:0005634 nucleus
GO:0005662 DNA replication factor A complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031902 late endosome membrane
GO:0035101 FACT complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160949
View Gene Order
ENSBTAG00000007749
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_198518
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PZL7 E9Q2M2
UniProt Splice Variant
Entrez Gene 72749
UniGene Mm.358749
RefSeq NM_025842 NM_183091
OMIM
CCDS CCDS27579 CCDS27580
HPRD
IMGT
MGI ID MGI:1919999
MGI Symbol Tonsl
EMBL AC156550 AC157566
GenPept
RNA Seq Atlas 66914 72749

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca