InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aadat

Summary

InnateDB Gene

IDBG-156441.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aadat

Gene Name

aminoadipate aminotransferase

Synonyms

Aadt; AI875679; Kat2; KATII; mKat-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000057228

Encoded Proteins

IDBP-156443

aminoadipate aminotransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109576:
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:60506124-60545677

Strand

Forward strand

Band

B3.1

Transcripts

ENSMUST00000079472

ENSMUSP00000078436

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016212	kynurenine-oxoglutarate transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0042803	protein homodimerization activity
GO:0047536	2-aminoadipate transaminase activity

Biological Process

GO:0006103	2-oxoglutarate metabolic process
GO:0006536	glutamate metabolic process
GO:0009058	biosynthetic process
GO:0019441	tryptophan catabolic process to kynurenine
GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0070189	kynurenine metabolic process
GO:0097052	L-kynurenine metabolic process