Version 5.4
Bos taurus Gene: AADAT
Summary
InnateDB Gene IDBG-629270.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AADAT
Gene Name kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms AADAT
Species Bos taurus
Ensembl Gene ENSBTAG00000010326
Encoded Proteins
IDBP-680669
kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109576:
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:1792852-1816770
Strand Reverse strand
Band
Transcripts
ENSBTAT00000013637 ENSBTAP00000013637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016212 kynurenine-oxoglutarate transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
GO:0047536 2-aminoadipate transaminase activity
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0006536 glutamate metabolic process
GO:0009058 biosynthetic process
GO:0070189 kynurenine metabolic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000109576
View Gene Order
ENSMUSG00000057228
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1298
Lysine catabolism pathway
REACT_916
Tryptophan catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_240936
Tryptophan catabolism pathway
REACT_239844
Lysine catabolism pathway
KEGG
hsa00380
Tryptophan metabolism pathway
hsa00300
Lysine biosynthesis pathway
hsa00310
Lysine degradation pathway
mmu00300
Lysine biosynthesis pathway
mmu00310
Lysine degradation pathway
mmu00380
Tryptophan metabolism pathway
INOH
INOH website
Lysine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.11485
RefSeq NM_001015551 XM_002689448 XM_005209789 XM_598886
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca