InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AADAT

Summary

InnateDB Gene

IDBG-44521.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AADAT

Gene Name

aminoadipate aminotransferase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000109576

Encoded Proteins

IDBP-44523

aminoadipate aminotransferase

IDBP-44525

aminoadipate aminotransferase

IDBP-475508

aminoadipate aminotransferase

IDBP-476322

aminoadipate aminotransferase

IDBP-476552

aminoadipate aminotransferase

IDBP-480649

aminoadipate aminotransferase

IDBP-477904

aminoadipate aminotransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:170060222-170091699

Strand

Reverse strand

Band

q33

Transcripts

ENST00000353187	ENSP00000226840
ENST00000337664	ENSP00000336808
ENST00000515480	ENSP00000423341
ENST00000509167	ENSP00000423190
ENST00000505906
ENST00000510340	ENSP00000425067
ENST00000507375	ENSP00000421389
ENST00000502392	ENSP00000423843

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0016212	kynurenine-oxoglutarate transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0042803	protein homodimerization activity
GO:0047536	2-aminoadipate transaminase activity

Biological Process

GO:0006103	2-oxoglutarate metabolic process
GO:0006536	glutamate metabolic process
GO:0006554	lysine catabolic process
GO:0006569	tryptophan catabolic process
GO:0009058	biosynthetic process
GO:0019441	tryptophan catabolic process to kynurenine
GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0070189	kynurenine metabolic process
GO:0097052	L-kynurenine metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000057228

View Gene Order

ENSBTAG00000010326

Not yet available

Pathways

NETPATH

REACTOME

REACT_1298

Lysine catabolism pathway

REACT_916

Tryptophan catabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00380

Tryptophan metabolism pathway

hsa00300

Lysine biosynthesis pathway

hsa00310

Lysine degradation pathway

INOH

INOH website

Lysine degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.529735 Hs.596402

RefSeq

NM_001286682 NM_001286683 NM_016228 NM_182662 XM_006714231

HUGO

OMIM

CCDS

CCDS3814 CCDS75209

HPRD

12392

IMGT

EMBL

GenPept

RNA Seq Atlas