InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grm4

Summary

InnateDB Gene

IDBG-156726.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm4

Gene Name

glutamate receptor, metabotropic 4

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000063239

Encoded Proteins

IDBP-401362

glutamate receptor, metabotropic 4

IDBP-401357

glutamate receptor, metabotropic 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124493:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:27422387-27513341

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000118489	ENSMUSP00000112578
ENSMUST00000118161	ENSMUSP00000113819
ENSMUST00000146277
ENSMUST00000147865

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001642	group III metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005516	calmodulin binding
GO:0008066	glutamate receptor activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007612	learning
GO:0043410	positive regulation of MAPK cascade
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005622	intracellular
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043195	terminal bouton
GO:0043198	dendritic shaft
GO:0048787	presynaptic active zone membrane