InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Loxl3

Summary

InnateDB Gene

IDBG-159383.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Loxl3

Gene Name

lysyl oxidase-like 3

Synonyms

Lor2; Loxl2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000693

Encoded Proteins

IDBP-159385

lysyl oxidase-like 3

IDBP-159387

lysyl oxidase-like 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115318:
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:83034173-83052562

Strand

Forward strand

Band

Transcripts

ENSMUST00000000707	ENSMUSP00000000707
ENSMUST00000101257	ENSMUSP00000098815
ENSMUST00000152679
ENSMUST00000155502

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Biological Process

GO:0001837	epithelial to mesenchymal transition
GO:0006898	receptor-mediated endocytosis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000115318

View Gene Order

ENSBTAG00000018578

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_150206

Crosslinking of collagen fibrils pathway

REACT_150180

Assembly of collagen fibrils and other multimeric structures pathway

REACT_150366

Elastic fibre formation pathway

REACT_118779

Extracellular matrix organization pathway

REACT_120729

Collagen formation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9Z175

TrEMBL

E9Q0X7

UniProt Splice Variant

Entrez Gene

16950

UniGene

Mm.380433

RefSeq

NM_013586

OMIM

CCDS

CCDS20266

HPRD

IMGT

MGI ID

MGI:1337004

MGI Symbol

Loxl3

EMBL

AC104324 AF053368 AF084363 AK030548 BC011298 CH466523

GenPept

AAC83205 AAC95338 AAH11298 BAC27016 EDK99047

RNA Seq Atlas

16950