Version 5.4
Homo sapiens Gene: LOXL3
Summary
InnateDB Gene IDBG-57846.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LOXL3
Gene Name lysyl oxidase-like 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115318
Encoded Proteins
IDBP-57848
lysyl oxidase-like 3
IDBP-242595
lysyl oxidase-like 3
IDBP-295476
lysyl oxidase-like 3
IDBP-295475
lysyl oxidase-like 3
IDBP-295474
lysyl oxidase-like 3
IDBP-380945
lysyl oxidase-like 3
IDBP-380946
lysyl oxidase-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:74532414-74555690
Strand Reverse strand
Band p13.1
Transcripts
ENST00000264094 ENSP00000264094
ENST00000393937 ENSP00000377512
ENST00000409249 ENSP00000387103
ENST00000409549 ENSP00000386696
ENST00000409986 ENSP00000386545
ENST00000420535 ENSP00000404026
ENST00000413469 ENSP00000398260
ENST00000470907
ENST00000481835
ENST00000484369
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004720 protein-lysine 6-oxidase activity
GO:0005044 scavenger receptor activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Biological Process
GO:0001837 epithelial to mesenchymal transition
GO:0006898 receptor-mediated endocytosis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000693
View Gene Order
ENSBTAG00000018578
Not yet available
Pathways
NETPATH
REACTOME
REACT_150206
Crosslinking of collagen fibrils pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_120729
Collagen formation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P58215
TrEMBL Q8N505
UniProt Splice Variant
Entrez Gene 84695
UniGene Hs.469045
RefSeq NM_001289164 NM_032603
HUGO HGNC:13869
OMIM 607163
CCDS CCDS74527 CCDS1953
HPRD 06200
IMGT
EMBL AC005033 AC005041 AF282619 AF284815 AF311313 BC033130 BC071865 CH471053 DQ378059
GenPept AAH33130 AAH71865 AAK51671 AAK63205 AAK91134 ABD23013 EAW99615 EAW99616
RNA Seq Atlas 84695

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca