Version 5.4
Mus musculus Gene: Nfib
Summary
InnateDB Gene IDBG-159419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nfib
Gene Name nuclear factor I/B
Synonyms 6720429L07Rik; CTF; E030026I10Rik; NF-I/B; NF1-B; NFI-B
Species Mus musculus
Ensembl Gene ENSMUSG00000008575
Encoded Proteins
IDBP-159379
nuclear factor I/B
IDBP-159423
nuclear factor I/B
IDBP-267071
nuclear factor I/B
IDBP-267073
nuclear factor I/B
IDBP-267075
nuclear factor I/B
IDBP-267077
nuclear factor I/B
IDBP-537537
nuclear factor I/B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147862:
Gene Information
Type Protein coding
Genomic Location Chromosome 4:82290173-82705750
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000064770 ENSMUSP00000067629
ENSMUST00000050872 ENSMUSP00000052863
ENSMUST00000107248 ENSMUSP00000102869
ENSMUST00000107247 ENSMUSP00000102868
ENSMUST00000107246 ENSMUSP00000102866
ENSMUST00000107245 ENSMUSP00000102865
ENSMUST00000122918
ENSMUST00000140874
ENSMUST00000148982
ENSMUST00000135024
ENSMUST00000155821 ENSMUSP00000123169
ENSMUST00000152588
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002062 chondrocyte differentiation
GO:0006260 DNA replication
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0008285 negative regulation of cell proliferation
GO:0010001 glial cell differentiation
GO:0021740 principal sensory nucleus of trigeminal nerve development
GO:0021960 anterior commissure morphogenesis
GO:0030324 lung development
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0043392 negative regulation of DNA binding
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060486 Clara cell differentiation
GO:0060509 Type I pneumocyte differentiation
GO:0060510 Type II pneumocyte differentiation
GO:0061141 lung ciliated cell differentiation
GO:0071679 commissural neuron axon guidance
GO:2000791 negative regulation of mesenchymal cell proliferation involved in lung development
GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0044300 cerebellar mossy fiber
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000147862
View Gene Order
ENSBTAG00000027442
Not yet available
Pathways
NETPATH
REACTOME
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_261233
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_233572
Gene Expression pathway
REACT_221403
RNA Polymerase III Transcription Termination pathway
REACT_237241
RNA Polymerase III Transcription pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_63
RNA Polymerase III Transcription Termination pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.404118 Mm.416761 Mm.470715 Mm.471772
RefSeq NM_001113209 NM_001113210 NM_001286127 NM_008687
OMIM
CCDS CCDS38790 CCDS51213
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca