Version 5.4
Homo sapiens Gene: NFIB
Summary
InnateDB Gene IDBG-50410.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFIB
Gene Name nuclear factor I/B
Synonyms CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B; NFI-RED; NFIB2; NFIB3
Species Homo sapiens
Ensembl Gene ENSG00000147862
Encoded Proteins
IDBP-50412
nuclear factor I/B
IDBP-50414
nuclear factor I/B
IDBP-50420
nuclear factor I/B
IDBP-50422
nuclear factor I/B
IDBP-50424
nuclear factor I/B
IDBP-235039
nuclear factor I/B
IDBP-235041
nuclear factor I/B
IDBP-235043
nuclear factor I/B
IDBP-807221
nuclear factor I/B
IDBP-587472
nuclear factor I/B
IDBP-807222
nuclear factor I/B
IDBP-807225
nuclear factor I/B
IDBP-807227
nuclear factor I/B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:14081843-14398983
Strand Reverse strand
Band p22.3
Transcripts
ENST00000380959 ENSP00000370346
ENST00000380953 ENSP00000370340
ENST00000380934 ENSP00000370321
ENST00000380924 ENSP00000370311
ENST00000380921 ENSP00000370308
ENST00000397581 ENSP00000380711
ENST00000397579 ENSP00000380709
ENST00000397575 ENSP00000380705
ENST00000493697 ENSP00000475362
ENST00000543693 ENSP00000442888
ENST00000606230 ENSP00000475813
ENST00000622101 ENSP00000480557
ENST00000622520 ENSP00000481181
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 2 [view]
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002062 chondrocyte differentiation
GO:0006260 DNA replication
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0008285 negative regulation of cell proliferation
GO:0010001 glial cell differentiation
GO:0021740 principal sensory nucleus of trigeminal nerve development
GO:0021960 anterior commissure morphogenesis
GO:0030324 lung development
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0043392 negative regulation of DNA binding
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060486 Clara cell differentiation
GO:0060509 Type I pneumocyte differentiation
GO:0060510 Type II pneumocyte differentiation
GO:0061141 lung ciliated cell differentiation
GO:0071679 commissural neuron axon guidance
GO:2000791 negative regulation of mesenchymal cell proliferation involved in lung development
GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0044300 cerebellar mossy fiber
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000008575
View Gene Order
ENSBTAG00000027442
Not yet available
Pathways
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_63
RNA Polymerase III Transcription Termination pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001190737 NM_001190738 NM_001282787 NM_005596 XM_005251469
HUGO
OMIM
CCDS CCDS55291 CCDS55292 CCDS6474 CCDS65007
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca