Version 5.4
Mus musculus Gene: Fstl1
Summary
InnateDB Gene IDBG-159696.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fstl1
Gene Name follistatin-like 1
Synonyms AI316791; AW107808; Fstl; TSC-36
Species Mus musculus
Ensembl Gene ENSMUSG00000022816
Encoded Proteins
IDBP-251082
follistatin-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22265692
Fstl1 acts as an endogenous Tlr4 agonist. Similar to LPS, Fstl1 induces tolerance to subsequent LPS stimulations.
InnateDB Annotation from Orthologs
Summary
PMID 22265692
[Homo sapiens] FSTL1 acts as an endogenous TLR4 agonist and has the ability to induce IL6 and IL8 production. Similar to LPS, FSTL1 induces tolerance to subsequent LPS stimulations.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163430:
This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:37776873-37836514
Strand Forward strand
Band B3
Transcripts
ENSMUST00000114763 ENSMUSP00000110411
ENSMUST00000152579
ENSMUST00000125279
ENSMUST00000135668
ENSMUST00000127495
ENSMUST00000123077
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008201 heparin binding
Biological Process
GO:0042594 response to starvation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163430
View Gene Order
ENSBTAG00000022155
Not yet available
Pathways
NETPATH
REACTOME
REACT_220505
Signaling by BMP pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12034
Signaling by BMP pathway
REACT_111102
Signal Transduction pathway
REACT_211837
Signaling by BMP pathway
REACT_214353
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.182434 Mm.471956
RefSeq NM_008047
OMIM
CCDS CCDS37339
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca