Version 5.4
| Mus musculus Gene: Atp6v1b2 | |||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||
| InnateDB Gene | IDBG-159808.6 | ||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
| Gene Symbol | Atp6v1b2 | ||||||||||||||||||||||||||
| Gene Name | ATPase, H+ transporting, lysosomal V1 subunit B2 | ||||||||||||||||||||||||||
| Synonyms | AI194269; AI790362; Atp6b2; HO57; R74844 | ||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000006273 | ||||||||||||||||||||||||||
| Encoded Proteins |
ATPase, H+ transporting, lysosomal V1 subunit B2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147416:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||
| Genomic Location | Chromosome 8:69088646-69113711 | ||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||
| Band | B3.3 | ||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||
| REACTOME |
Disease pathway
Signaling by Insulin receptor pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Iron uptake and transport pathway
Transmembrane transport of small molecules pathway
Insulin receptor recycling pathway
Signal Transduction pathway
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| KEGG |
Oxidative phosphorylation pathway
Phagosome pathway
Collecting duct acid secretion pathway
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| INOH | |||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||
| REACTOME |
Transferrin endocytosis and recycling pathway
Iron uptake and transport pathway
Insulin receptor recycling pathway
Signaling by Insulin receptor pathway
Phagosomal maturation (early endosomal stage) pathway
Transmembrane transport of small molecules pathway
Signal Transduction pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Iron uptake and transport pathway
Transmembrane transport of small molecules pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Signal Transduction pathway
Signaling by Insulin receptor pathway
Insulin receptor recycling pathway
Disease pathway
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| KEGG |
Vibrio cholerae infection pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Oxidative phosphorylation pathway
Collecting duct acid secretion pathway
Phagosome pathway
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| INOH | |||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||||||
| SwissProt | P62814 | ||||||||||||||||||||||||||
| TrEMBL | B0LAC8 | ||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||
| Entrez Gene | 11966 | ||||||||||||||||||||||||||
| UniGene | Mm.392573 | ||||||||||||||||||||||||||
| RefSeq | NM_007509 | ||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||
| CCDS | CCDS40358 | ||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||
| MGI ID | MGI:109618 | ||||||||||||||||||||||||||
| MGI Symbol | Atp6v1b2 | ||||||||||||||||||||||||||
| EMBL | AK146499 AK151200 AK151322 AK151586 AK152718 AK152766 AK159133 AK159153 AK159586 AK159701 AK159986 AK160080 AK160854 AK166669 AK168852 AK169155 AK169270 BC012497 BC046302 BC085300 EF437356 U13838 Y12634 | ||||||||||||||||||||||||||
| GenPept | AAC52411 AAH12497 AAH46302 AAH85300 ABS83522 BAE27215 BAE30197 BAE30303 BAE30526 BAE31441 BAE31479 BAE34845 BAE34860 BAE35206 BAE35300 BAE35536 BAE35612 BAE36047 BAE38930 BAE40674 BAE40934 BAE41031 CAA73182 | ||||||||||||||||||||||||||
| RNA Seq Atlas | 11966 | ||||||||||||||||||||||||||