Version 5.4
Mus musculus Gene: Card10
Summary
InnateDB Gene IDBG-159820.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Card10
Gene Name caspase recruitment domain family, member 10
Synonyms AI449026; Bimp1; Carma3
Species Mus musculus
Ensembl Gene ENSMUSG00000033170
Encoded Proteins
IDBP-627613
caspase recruitment domain family, member 10
IDBP-627614
caspase recruitment domain family, member 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100065:
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78775138-78803042
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000071115
ENSMUST00000164826 ENSMUSP00000129513
ENSMUST00000170584 ENSMUSP00000131003
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0042981 regulation of apoptotic process
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100065
View Gene Order
ENSBTAG00000015044
Not yet available
Cross-References
SwissProt
TrEMBL E9PUV9
UniProt Splice Variant
Entrez Gene 105844
UniGene Mm.17629
RefSeq NM_130859 XM_006520253
OMIM
CCDS CCDS27623
HPRD
IMGT
MGI ID MGI:2146012
MGI Symbol Card10
EMBL AF363456 AL592169 BC060203
GenPept AAH60203 AAK60136
RNA Seq Atlas 105844

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca