Version 5.4
Bos taurus Gene: BT.103700
Summary
InnateDB Gene IDBG-646513.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.103700
Gene Name probable E3 ubiquitin-protein ligase HERC1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019474
Encoded Proteins
IDBP-699334
hect domain and RCC1-like domain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103657:
This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:46241889-46455782
Strand Forward strand
Band
Transcripts
ENSBTAT00000061038 ENSBTAP00000053409
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
Biological Process
GO:0008152 metabolic process
GO:0010507 negative regulation of autophagy
GO:0016567 protein ubiquitination
GO:0021702 cerebellar Purkinje cell differentiation
GO:0031175 neuron projection development
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000103657
View Gene Order
ENSMUSG00000038664
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MNS0 Q862P0
UniProt Splice Variant
Entrez Gene 538029
UniGene Bt.103700 Bt.103990 Bt.104372 Bt.104375 Bt.104458
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB098939 DAAA02028744 DAAA02028745 DAAA02028746
GenPept BAC56429
RNA Seq Atlas 538029

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca