InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NLRP6

Summary

InnateDB Gene

IDBG-16041.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRP6

Gene Name

NLR family, pyrin domain containing 6

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000174885

Encoded Proteins

IDBP-16045

NLR family, pyrin domain containing 6

IDBP-589489

NLR family, pyrin domain containing 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 12633874

Regulator of NF-kappaB and CASP1, angiotensin II and vasopressin receptor

PMID 22763455

NLRP6 is a negative regulator of inflammatory signalling and impedes the clearance of both Gram-positive and -negative bacterial pathogens. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22763455

[Mus musculus] Nlrp6 is a negative regulator of inflammatory signalling and impedes the clearance of both Gram-positive and -negative bacterial pathogens.

PMID 26494172

[Mus musculus] Nlrp6 functions with Dhx15 as a viral RNA sensor to induce IFN-stimulated genes, and this effect is especially important in the intestinal tract.

PMID 26638072

[Mus musculus] Microbiota-associated metabolites modulate Nlrp6 inflammasome signalling, epithelial Il18 secretion, and anti-microbial pathways.

Entrez Gene

Summary

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:278365-285359

Strand

Forward strand

Band

p15.5

Transcripts

ENST00000312165	ENSP00000309767
ENST00000534750	ENSP00000433617
ENST00000527946

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005000	vasopressin receptor activity
GO:0005524	ATP binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0009617	response to bacterium
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0042060	wound healing
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043409	negative regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0050727	regulation of inflammatory response
GO:0050777	negative regulation of immune response

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0031965	nuclear membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038745

View Gene Order

ENSBTAG00000001076

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.352611

RefSeq

NM_001276700 NM_138329

HUGO

OMIM

CCDS

CCDS60680 CCDS7693

HPRD

14806

IMGT

EMBL

GenPept

RNA Seq Atlas