Version 5.4
Bos taurus Gene: NLRP6
Summary
InnateDB Gene IDBG-641962.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLRP6
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001076
Encoded Proteins
IDBP-694373
NLR family, pyrin domain containing 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 12633874
[Homo sapiens] Regulator of NF-kappaB and CASP1, angiotensin II and vasopressin receptor
PMID 22763455
[Homo sapiens] NLRP6 is a negative regulator of inflammatory signalling and impedes the clearance of both Gram-positive and -negative bacterial pathogens. (Demonstrated in mice)
PMID 22763455
[Mus musculus] Nlrp6 is a negative regulator of inflammatory signalling and impedes the clearance of both Gram-positive and -negative bacterial pathogens.
PMID 26494172
[Mus musculus] Nlrp6 functions with Dhx15 as a viral RNA sensor to induce IFN-stimulated genes, and this effect is especially important in the intestinal tract.
PMID 26638072
[Mus musculus] Microbiota-associated metabolites modulate Nlrp6 inflammasome signalling, epithelial Il18 secretion, and anti-microbial pathways.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174885:
The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:107214414-107220027
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001428 ENSBTAP00000001428
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005524 ATP binding
Biological Process
GO:0006952 defense response
GO:0009617 response to bacterium
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0042060 wound healing
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043409 negative regulation of MAPK cascade
GO:0050727 regulation of inflammatory response
GO:0050777 negative regulation of immune response
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000174885
View Gene Order
ENSMUSG00000038745
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq XM_002683733 XM_581339
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca