Mus musculus Gene: Gmip
Summary
InnateDB Gene IDBG-160585.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gmip
Gene Name Gem-interacting protein
Synonyms 5031419I10Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000036246
Encoded Proteins
Gem-interacting protein
Gem-interacting protein
Gem-interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089639:
This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternatively spliced variants that encode different protein isoforms have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:69808679-69821870
Strand Forward strand
Band B3.3
Transcripts
ENSMUST00000036074 ENSMUSP00000045676
ENSMUST00000123453 ENSMUSP00000116542
ENSMUST00000143744
ENSMUST00000156620
ENSMUST00000154903
ENSMUST00000138269
ENSMUST00000127114
ENSMUST00000142659 ENSMUSP00000114525
ENSMUST00000144540
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0034259 negative regulation of Rho GTPase activity
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Signaling by Rho GTPases pathway
Rho GTPase cycle pathway
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Rho GTPase cycle pathway
Signaling by Rho GTPases pathway
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 78816
UniGene Mm.324305 Mm.446317
RefSeq NM_198101
OMIM
CCDS CCDS22350
HPRD
IMGT
MGI ID MGI:1926066
MGI Symbol Gmip
EMBL
GenPept
RNA Seq Atlas 78816