Version 5.4
Homo sapiens Gene: GMIP
Summary
InnateDB Gene IDBG-40107.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GMIP
Gene Name GEM interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000089639
Encoded Proteins
IDBP-40109
GEM interacting protein
IDBP-762116
IDBP-760621
IDBP-760941
IDBP-765080
IDBP-763443
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternatively spliced variants that encode different protein isoforms have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:19629476-19643667
Strand Reverse strand
Band p13.11
Transcripts
ENST00000203556 ENSP00000203556
ENST00000587238 ENSP00000467054
ENST00000593186 ENSP00000465108
ENST00000591047 ENSP00000466045
ENST00000587713
ENST00000588171 ENSP00000468662
ENST00000586269
ENST00000587205 ENSP00000467946
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0034259 negative regulation of Rho GTPase activity
GO:0035556 intracellular signal transduction
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036246
View Gene Order
ENSBTAG00000015144
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.49427 Hs.605621
RefSeq NM_001288998 NM_001288999 NM_016573 XM_005259927
HUGO
OMIM
CCDS CCDS12408 CCDS74318
HPRD 11005
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca