InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lpar2

Summary

InnateDB Gene

IDBG-160734.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lpar2

Gene Name

lysophosphatidic acid receptor 2

Synonyms

Edg4; IPA2; LPA2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031861

Encoded Proteins

IDBP-160738

lysophosphatidic acid receptor 2

IDBP-619787

lysophosphatidic acid receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064547:
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:69822429-69831102

Strand

Forward strand

Band

B3.3

Transcripts

ENSMUST00000034325	ENSMUSP00000034325
ENSMUST00000164890	ENSMUSP00000128261

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0070915	lysophosphatidic acid receptor activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0035025	positive regulation of Rho protein signal transduction
GO:0043410	positive regulation of MAPK cascade