Version 5.4
Mus musculus Gene: Spnb4
Summary
InnateDB Gene IDBG-160792.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spnb4
Gene Name spectrin beta 4
Synonyms 1700022P15Rik; 5830426A08Rik; dyn; lnd; nmf261; nmf379; qv; ROSA62; SpbIV; Spnb4
Species Mus musculus
Ensembl Gene ENSMUSG00000011751
Encoded Proteins
IDBP-160794
spectrin beta 4
IDBP-264693
spectrin beta 4
IDBP-264695
spectrin beta 4
IDBP-264697
spectrin beta 4
IDBP-540818
spectrin beta 4
IDBP-622184
spectrin beta 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160460:
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27356383-27447686
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000011895 ENSMUSP00000011895
ENSMUST00000108364 ENSMUSP00000104001
ENSMUST00000108363 ENSMUSP00000104000
ENSMUST00000108362 ENSMUSP00000103999
ENSMUST00000138087
ENSMUST00000152572 ENSMUSP00000120738
ENSMUST00000137414
ENSMUST00000172269 ENSMUSP00000132807
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0019902 phosphatase binding
GO:0030506 ankyrin binding
GO:0030507 spectrin binding
Biological Process
GO:0002028 regulation of sodium ion transport
GO:0007409 axonogenesis
GO:0007605 sensory perception of sound
GO:0007628 adult walking behavior
GO:0009566 fertilization
GO:0010459 negative regulation of heart rate
GO:0019226 transmission of nerve impulse
GO:0021952 central nervous system projection neuron axonogenesis
GO:0022414 reproductive process
GO:0030534 adult behavior
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0034613 cellular protein localization
GO:0040018 positive regulation of multicellular organism growth
GO:0045162 clustering of voltage-gated sodium channels
GO:0061337 cardiac conduction
GO:0090002 establishment of protein localization to plasma membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0008091 spectrin
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0016605 PML body
GO:0030424 axon
GO:0033268 node of Ranvier
GO:0033270 paranode region of axon
GO:0043025 neuronal cell body
GO:0043194 axon initial segment
GO:0043203 axon hillock
GO:0070852 cell body fiber
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160460
View Gene Order
ENSBTAG00000004751
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q91ZE6 Q9EQM0
UniProt Splice Variant
Entrez Gene 80297
UniGene Mm.409235 Mm.421849 Mm.459123 Mm.463815
RefSeq XM_006540437 NM_001199234 NM_001199235 NM_001199236 NM_032610 XM_006540436
OMIM
CCDS CCDS21019 CCDS57530
HPRD
IMGT
MGI ID MGI:1890574
MGI Symbol Sptbn4
EMBL AC157561 AC158304 AF203696 AY032655 AY032692 AY032693 AY032694 AY032695 AY032696 AY032697 AY032698 AY032699 AY032700 AY032701 AY032702 AY032703 AY032704 AY032705 AY032706 AY032707 AY032708 AY032709 AY032710 AY032711 AY032712 AY032713 AY032714 AY032715 AY032716 AY032717 AY032718 AY032719 AY032720
GenPept AAG35643 AAK38731 AAK49014
RNA Seq Atlas 80297

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca