InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SPTBN4

Summary

InnateDB Gene

IDBG-637932.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPTBN4

Gene Name

spectrin beta chain, brain 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004751

Encoded Proteins

IDBP-690001

spectrin, beta, non-erythrocytic 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160460:
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:50077666-50154685

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007434

ENSBTAP00000007434

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0019902	phosphatase binding
GO:0030507	spectrin binding

Biological Process

GO:0002028	regulation of sodium ion transport
GO:0007409	axonogenesis
GO:0007605	sensory perception of sound
GO:0007628	adult walking behavior
GO:0009566	fertilization
GO:0010459	negative regulation of heart rate
GO:0019226	transmission of nerve impulse
GO:0021952	central nervous system projection neuron axonogenesis
GO:0022414	reproductive process
GO:0030534	adult behavior
GO:0033135	regulation of peptidyl-serine phosphorylation
GO:0034613	cellular protein localization
GO:0040018	positive regulation of multicellular organism growth
GO:0045162	clustering of voltage-gated sodium channels
GO:0061337	cardiac conduction

Cellular Component

GO:0008091	spectrin
GO:0016020	membrane
GO:0030424	axon
GO:0033270	paranode region of axon
GO:0043025	neuronal cell body
GO:0043194	axon initial segment
GO:0043203	axon hillock
GO:0070852	cell body fiber

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000160460

View Gene Order

ENSMUSG00000011751

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22266

Interaction between L1 and Ankyrins pathway

REACT_22205

L1CAM interactions pathway

REACT_18334

NCAM signaling for neurite out-growth pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.105931

RefSeq

NM_001192910 XM_005218990

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas