InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pick1

Summary

InnateDB Gene

IDBG-161096.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pick1

Gene Name

protein interacting with C kinase 1

Synonyms

Prkcabp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000068206

Encoded Proteins

IDBP-161098

protein interacting with C kinase 1

IDBP-161100

protein interacting with C kinase 1

IDBP-620883

protein interacting with C kinase 1

IDBP-620886

protein interacting with C kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100151:
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:79229173-79256674

Strand

Forward strand

Band

Transcripts

ENSMUST00000053926	ENSMUSP00000061125
ENSMUST00000018295	ENSMUSP00000018295
ENSMUST00000113954
ENSMUST00000163571	ENSMUSP00000128126
ENSMUST00000165609
ENSMUST00000169548
ENSMUST00000166417
ENSMUST00000171365
ENSMUST00000166155	ENSMUSP00000129468
ENSMUST00000168513
ENSMUST00000172162
ENSMUST00000171581

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006605	protein targeting
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0015844	monoamine transport

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0042734	presynaptic membrane
GO:0097481	neuronal postsynaptic density

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000100151

View Gene Order

ENSBTAG00000015268

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_18422

Trafficking of GluR2-containing AMPA receptors pathway

REACT_18307

Trafficking of AMPA receptors pathway

REACT_13685

Neuronal System pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_18347

Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.259464 Mm.416480

RefSeq

NM_001045558 NM_008837 XM_006521627 XM_006543258

OMIM

CCDS

CCDS27635

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas