InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PRKCABP

Summary

InnateDB Gene

IDBG-641553.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKCABP

Gene Name

PRKCA-binding protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015268

Encoded Proteins

IDBP-693935

PRKCA-binding protein

IDBP-693940

PRKCA-binding protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100151:
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:110346675-110363542

Strand

Forward strand

Band

Transcripts

ENSBTAT00000042708	ENSBTAP00000040340
ENSBTAT00000020311	ENSBTAP00000020311

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016301	kinase activity
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006605	protein targeting
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0015844	monoamine transport
GO:0016310	phosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0042734	presynaptic membrane
GO:0097481	neuronal postsynaptic density

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000100151

View Gene Order

ENSMUSG00000068206

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_18422

Trafficking of GluR2-containing AMPA receptors pathway

REACT_18307

Trafficking of AMPA receptors pathway

REACT_13685

Neuronal System pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_18347

Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.15862

RefSeq

NM_001035401 XM_005207328 XM_005207329 XM_005207330 XM_005207332

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas