Version 5.4
Mus musculus Gene: Sel1l
Summary
InnateDB Gene IDBG-161609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sel1l
Gene Name sel-1 suppressor of lin-12-like (C. elegans)
Synonyms AW493766; mKIAA4137; Sel1h
Species Mus musculus
Ensembl Gene ENSMUSG00000020964
Encoded Proteins
IDBP-161611
sel-1 suppressor of lin-12-like (C. elegans)
IDBP-621634
sel-1 suppressor of lin-12-like (C. elegans)
IDBP-711111
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071537:
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:91806043-91849157
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000021347 ENSMUSP00000021347
ENSMUST00000165282
ENSMUST00000167466 ENSMUSP00000129384
ENSMUST00000166691
ENSMUST00000171465
ENSMUST00000167594
ENSMUST00000171959
ENSMUST00000172246
ENSMUST00000169843
ENSMUST00000178462 ENSMUSP00000136087
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0034976 response to endoplasmic reticulum stress
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000071537
View Gene Order
ENSBTAG00000008083
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_233316
Hedgehog ligand biogenesis pathway
REACT_248271
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_196494
Pre-NOTCH Expression and Processing pathway
REACT_232469
Hh ligand biogenesis disease pathway
REACT_196517
Pre-NOTCH Processing in Golgi pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_188257
Signal Transduction pathway
REACT_231152
Signaling by NOTCH pathway
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118798
Pre-NOTCH Processing in Golgi pathway
REACT_228190
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_111102
Signal Transduction pathway
REACT_228209
Hh ligand biogenesis disease pathway
REACT_228111
Hedgehog ligand biogenesis pathway
REACT_299
Signaling by NOTCH pathway
REACT_116125
Disease pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.250605 Mm.413398
RefSeq NM_001039089 NM_011344
OMIM
CCDS CCDS26091 CCDS49137
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca