Version 5.4
Mus musculus Gene: Htr3a
Summary
InnateDB Gene IDBG-162250.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Htr3a
Gene Name 5-hydroxytryptamine (serotonin) receptor 3A
Synonyms 5-HT3
Species Mus musculus
Ensembl Gene ENSMUSG00000032269
Encoded Proteins
IDBP-162252
5-hydroxytryptamine (serotonin) receptor 3A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166736:
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:48899214-48911099
Strand Reverse strand
Band A5.3
Transcripts
ENSMUST00000003826 ENSMUSP00000003826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004993 serotonin receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005232 serotonin-activated cation-selective channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0051378 serotonin binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007210 serotonin receptor signaling pathway
GO:0042220 response to cocaine
GO:0045471 response to ethanol
GO:0071363 cellular response to growth factor stimulus
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0043025 neuronal cell body
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166736
View Gene Order
ENSBTAG00000010791
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25387
Ligand-gated ion channel transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9QLC0 Q6LCB3 Q8K1F4
UniProt Splice Variant
Entrez Gene 15561
UniGene Mm.4831
RefSeq NM_001099644 NM_013561
OMIM
CCDS CCDS52788
HPRD
IMGT
MGI ID MGI:96282
MGI Symbol Htr3a
EMBL AF513221 BC145743 CT009741 U73442
GenPept AAB71735 AAI45744 AAM47014
RNA Seq Atlas 15561

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca