Version 5.4
Mus musculus Gene: Pklr
Summary
InnateDB Gene IDBG-162642.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pklr
Gene Name pyruvate kinase liver and red blood cell
Synonyms Pk-1; Pk1; R-PK
Species Mus musculus
Ensembl Gene ENSMUSG00000041237
Encoded Proteins
IDBP-162644
pyruvate kinase liver and red blood cell
IDBP-266579
pyruvate kinase liver and red blood cell
IDBP-542415
pyruvate kinase liver and red blood cell
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22022264
Pklr is recruited by hepatitis C virus early in infection as a sensor to trigger the induction of Irf3-dependent genes. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 22022264
[Homo sapiens] PKLR is recruited by hepatitis C virus early in infection as a sensor to trigger the induction of IRF3-dependent genes.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143627:
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:89136142-89146784
Strand Forward strand
Band F1
Transcripts
ENSMUST00000047111 ENSMUSP00000035417
ENSMUST00000107482 ENSMUSP00000103106
ENSMUST00000151591
ENSMUST00000127058 ENSMUSP00000119392
ENSMUST00000148097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0030955 potassium ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0006754 ATP biosynthetic process
GO:0007584 response to nutrient
GO:0009408 response to heat
GO:0009749 response to glucose
GO:0010038 response to metal ion
GO:0010226 response to lithium ion
GO:0014070 response to organic cyclic compound
GO:0016310 phosphorylation
GO:0032869 cellular response to insulin stimulus
GO:0033198 response to ATP
GO:0042866 pyruvate biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0051591 response to cAMP
GO:0051707 response to other organism
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143627
View Gene Order
ENSBTAG00000017056
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04950
Maturity onset diabetes of the young pathway
mmu04930
Type II diabetes mellitus pathway
mmu04910
Insulin signaling pathway pathway
mmu00010
Glycolysis / Gluconeogenesis pathway
mmu00620
Pyruvate metabolism pathway
mmu00230
Purine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00230
Purine metabolism pathway
hsa04910
Insulin signaling pathway pathway
hsa04950
Maturity onset diabetes of the young pathway
hsa04930
Type II diabetes mellitus pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
Glycolysis Gluconeogenesis pathway
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.383180
RefSeq NM_001099779 NM_013631 XM_006501134 XM_006501135
OMIM
CCDS CCDS17489 CCDS50957
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca